Participation in colorectal cancer screening trials after first-time
                    invitation: a systematic review

C. Khalid-de Bakker; D. Jonkers; K. Smits; I. Mesters; A. Masclee; R. Stockbrügger

doi:10.1055/s-0031-1291430

Endoscopy, Table of Contents

Endoscopy 2011; 43(12): 1059-1086
DOI: 10.1055/s-0031-1291430

Original article

Participation in colorectal cancer screening trials after first-time invitation: a systematic review

C. Khalid-de Bakker

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC), The Netherlands

,

D. Jonkers

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC), The Netherlands

,

K. Smits

²Department of Pathology, Maastricht University Medical Centre (MUMC), The Netherlands

,

I. Mesters

³Department of Epidemiology, Maastricht University Medical Centre (MUMC), The Netherlands

,

A. Masclee

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC), The Netherlands

,

R. Stockbrügger

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Centre (MUMC), The Netherlands

› Author Affiliations

Abstract

Background and study aim: Colorectal cancer (CRC) screening is implemented by an increasing number of countries. Participation rates of screening programs influence the health benefit and cost – effectiveness of the applied method. The aim was to systematically review participation rate after first-time invitation for CRC screening with fecal occult blood test (FOBT), sigmoidoscopy, colonoscopy, and/or computed tomography (CT) colonography.

Methods: A systematic literature search was performed prior to October 1 2009. Prospective CRC screening studies of unselected populations reporting participation rates were included.

Results: After meta-analyses, overall participation rates were found to be 47 % for FOBT, 42 % for fecal immunologic tests (FITs), 35 % for sigmoidoscopy, 41 % for sigmoidoscopy combined with FIT/FOBT, 28 % for colonoscopy, and 22 % for CT colonography. Studies comparing screening methods showed higher participation rates for less invasive methods. Studies comparing invitation methods showed higher participation rates with general practitioner involvement, a more personalized recruitment approach, and reduction of barriers that discourage participation.

Conclusions: Knowledge of identified factors affecting CRC screening participation can be used to improve screening programs.

Full Text

References

References
1 Parkin DM, Bray F, Ferlay J et al. Global Cancer Statistics, 2002. CA Cancer J Clin 2005; 55: 74-108
2 Bokemeyer B, Bock H, Huppe D et al. Screening colonoscopy for colorectal cancer prevention: Results from a German online registry on 269 000 cases. Eur J Gastroenterol Hepatol 2009; 21: 650-655
3 Hewitson P, Glasziou P, Irwig L et al. Screening for colorectal cancer using the faecal occult blood test, Hemoccult. Cochrane Database Syst Rev 2007; CD001216
4 Towler B, Irwig L, Glasziou P et al. A systematic review of the effects of screening for colorectal cancer using the faecal occult blood test, Hemoccult. BMJ 1998; 317: 559-565
5 Atkin WS, Edwards R, Kralj-Hans I et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010; 375: 1624-1633
6 Benson VS, Patnick J, Davies AK et al. Colorectal cancer screening: A comparison of 35 initiatives in 17 countries. Int J Cancer 2008; 122: 1357-1367
7 Vijan S, Hwang EW, Hofer TP et al. Which colon cancer screening test? A comparison of costs, effectiveness, and compliance. . Am J Med 2001; 111: 593-601
8 Frazier AL, Colditz GA, Fuchs CS et al. Cost-effectiveness of screening for colorectal cancer in the general population. JAMA 2000; 284: 1954-1961
9 Lieberman DA. Cost-effectiveness model for colon cancer screening. Gastroenterology 1995; 109: 1781-1790
10 Howard K, Salkeld G, Irwig L et al. High participation rates are not necessary for cost-effective colorectal cancer screening. J Med Screen 2005; 12: 96-102
11 Vernon SW. Review: participation in colorectal cancer screening. J Natl Cancer Inst 1997; 89: 1406-1422
12 Bowie JV, Curbow BA, Garza MA et al. A review of breast, cervical, and colorectal cancer screening interventions in older women. Cancer Control 2005; 12: 58-69
13 Beydoun H, Beydoun M. Predictors of colorectal cancer screening behaviors among average-risk older adults in the United States. Cancer Causes Control 2008; 19: 339-359 [Epub 2007 Dec 18]
14 Subramanian S, Klosterman M, Amonkar MM et al. Adherence with colorectal cancer screening guidelines: a review. Prev Med 2004; 38: 536-550
15 Vernon SW. Participation in colorectal cancer screening: a review. J Natl Cancer Inst 1997; 89: 1406-1422
16 Weed DL. Methodologic guidelines for review papers. J Natl Cancer Inst 1997; 89: 6-7
17 Higgins JPT, Green S. (editors). Cochrane handbook for systematic reviews of interventions [updated September 2008]. The Cochrane Collaboration; 2008 www.cochrane-handbook.org
18 Review Manager (RevMan) [computer program]. Version 5.0. The Cochrane Collaboration; 2008
19 Giorgi Rossi P, Federici A, Bartolozzi F et al. Understanding non-compliance to colorectal cancer screening: a case control study, nested in a randomised trial [ISRCTN83029072]. BMC Public Health 2005; 5: 139-139
20 Deutekom M, Van Rijn AF, Dekker E et al. Uptake of faecal occult blood test colorectal cancer screening by different ethnic groups in the Netherlands. Eur J Public Health 2009; 19: 400-402
21 Forbes GM, Fritschi L, Mendelson RM et al. Influences on participation in a community-based colorectal neoplasia screening program by virtual colonoscopy in Australia. Aust N Z J Public Health 2004; 28: 283-287
22 Whynes DK, Frew EJ, Manghan CM et al. Colorectal cancer, screening and survival: the influence of socio-economic deprivation. Public Health 2003; 117: 389-395
23 Farrands PA, Hardcastle JD, Chamberlain J et al. Factors affecting compliance with screening for colorectal cancer. Community Med 1984; 6: 12-19
24 Larsen IK, Grotmol T, Almendingen K et al. Lifestyle characteristics among participants in a Norwegian colorectal cancer screening trial. Eur J Cancer Prev 2006; 15: 10-19
25 Blom J, Yin L, Liden A et al. Toward understanding nonparticipation in sigmoidoscopy screening for colorectal cancer. Int J Cancer 2008; 122: 1618-1623
26 Vernon SW, Acquavella JF, Yarborough CM et al. Reasons for participation and nonparticipation in a colorectal cancer screening program for a cohort of high risk polypropylene workers. J Occup Med 1990; 32: 46-51
27 Herbert C, Launoy G, Gignoux M. Factors affecting compliance with colorectal cancer screening in France: differences between intention to participate and actual participation. Eur J Cancer Prev 1997; 6: 44-52
28 Bretthauer M, Gondal G, Larsen K et al. Design, organization and management of a controlled population screening study for detection of colorectal neoplasia: attendance rates in the NORCCAP study (Norwegian Colorectal Cancer Prevention). Scand J Gastroenterol 2002; 37: 568-573
29 Niv Y, Lev-El M, Fraser G et al. Protective effect of faecal occult blood test screening for colorectal cancer: worse prognosis for screening refusers. Gut 2002; 50: 33-37
30 Stroup D, Berlin J, Morton S et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-2012
31 Crotta S, Castiglione G, Grazzini G et al. Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community. Eur J Gastroenterol Hepatol 2004; 16: 33-37
32 Grazzini G, Castiglione G, Ciabattoni C et al. Colorectal cancer screening programme by faecal occult blood test in Tuscany: first round results. Eur J Cancer Prev 2004; 13: 19-26
33 Berry DP, Clarke P, Hardcastle JD et al. Randomized trial of the addition of flexible sigmoidoscopy to faecal occult blood testing for colorectal neoplasia population screening. Br J Surg 1997; 84: 1274-1276
34 UK Colorectal Cancer Screening Pilot Group. Results of the first round of a demonstration pilot of screening for colorectal cancer in the United Kingdom. BMJ 2004; 329: 133
35 Steele RJ, McClements PL, Libby G et al. Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer. Gut 2009; 58: 530-535
36 Dybdahl JH, Haug K, Bakkevold K et al. Screening for occult faecal blood loss in a community by means of Hemoccult II slides and a tetramethylbenzidine test. Scand J Gastroenterol 1984; 19: 343-349
37 Lindholm E, Berglund B, Haglind E et al. Factors associated with participation in screening for colorectal cancer with faecal occult blood testing. Scand J Gastroenterol 1995; 30: 171-176
38 Carlsson U, Ekelund G, Eriksson R et al. Evaluation of possibilities for mass screening for colorectal cancer with Hemoccult fecal blood test. Dis Colon Rectum 1986; 29: 553-557
39 Brevinge H, Lindholm E, Buntzen S et al. Screening for colorectal neoplasia with faecal occult blood testing compared with flexible sigmoidoscopy directly in a 55–56 years’ old population. Int J Colorect Dis 1997; 12: 291-295
40 Malila N, Oivanen T, Malminiemi O et al. Test, episode, and programme sensitivities of screening for colorectal cancer as a public health policy in Finland: experimental design. [see comment]. BMJ 2008; 337: 2261
41 Hakkinen I, Paasivuo R, Partanen P. Screening of colorectal tumours using an improved faecal occult blood test. Quantitative aspects. Gut 1988; 29: 1194-1197
42 Malila N, Hakama M, Pukkala E. A 25-year follow-up of a population screened with faecal occult blood test in Finland. Acta Oncol 2007; 46: 1103-1106
43 Kronborg O, Fenger C, Sondergaard O et al. Initial mass screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen in Denmark. Scand J Gastroenterol 1987; 22: 677-686
44 Rasmussen M, Kronborg O, Fenger C et al. Possible advantages and drawbacks of adding flexible sigmoidoscopy to hemoccult-II in screening for colorectal cancer. A randomized study. Scand J Gastroenterol 1999; 34: 73-78
45 Adamsen S, Kronborg O. Acceptability and compliance in screening for colorectal cancer with fecal occult blood test. Scand J Gastroenterol 1984; 19: 531-534
46 van Rossum LG, van Rijn AF, Laheij RJ et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology 2008; 135: 82-90
47 Hol L, Wilschut JA, van Ballegooijen M et al. Screening for colorectal cancer: random comparison of guaiac and immunochemical faecal occult blood testing at different cut-off levels. Br J Cancer 2009; 100: 1103-1110
48 Peris M, Espinas JA, Munoz L et al. Lessons learnt from a population-based pilot programme for colorectal cancer screening in Catalonia (Spain). J Med Screen 2007; 14: 81-86
49 Tarraga P, Garcia-Olmo D, Celada A et al. Colorectal cancer screening through detection of fecal occult blood in a controlled health zone. Rev Esp Enferm Dig 1999; 91: 335-344
50 Hardcastle JD, Chamberlain JO, Robinson MH et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 1996; 348: 1472-1477
51 Box V, Nichols S, Lallemand RC et al. Haemoccult compliance rates and reasons for non-compliance. Public Health 1984; 98: 16-25
52 Hart AR, Gay SP, Donnelly A et al. Screening for colorectal cancer in Market Harborough, UK: A community-based programme. Eur J Gastroenterol Hepatol 1994; 6: 519-522
53 Marjoram J, Strachan R, Allan A et al. Screening for colorectal cancer: a general-practice-based study. Br J Gen Pract 1996; 46: 283-286
54 Verne J, Kettner J, Mant D et al. Self-administered faecal occult blood tests do not increase compliance with screening for colorectal cancer: results of a randomized controlled trial. Eur J Cancer Prev 1993; 2: 301-305
55 Hardcastle JD, Balfour TW, Amar SS. Screening for symptomless colorectal cancer by testing for occult blood in general practice. Lancet 1980; 1: 791-793
56 Farrands PA, Hardcastle JD. Colorectal screening by a self-completion questionnaire. Gut 1984; 25: 445-447
57 Mant D, Fuller A, Northover J et al. Patient compliance with colorectal cancer screening in general practice. Br J Gen Pract 1992; 42: 18-20
58 Hart AR, Barone TL, Gay SP et al. The effect on compliance of a health education leaflet in colorectal cancer screening in general practice in central England. J Epidemiol Community Health 1997; 51: 187-191
59 Verne JE, Aubrey R, Love SB et al. Population based randomized study of uptake and yield of screening by flexible sigmoidoscopy compared with screening by faecal occult blood testing. BMJ 1998; 317: 182-185
60 Jansen JH. Participation in the first and second round of a mass-screening for colorectal cancer. Soc Sci Med 1984; 18: 633-636
61 Goulard H, Boussac-Zarebska M, Ancelle-Park R et al. French colorectal cancer screening pilot programme: results of the first round. J Med Screen 2008; 15: 143-148
62 Launoy G, Smith TC, Duffy SW et al. Colorectal cancer mass-screening: estimation of faecal occult blood test sensitivity, taking into account cancer mean sojourn time. Int J Cancer 1997; 73: 220-224
63 Manfredi S, Piette C, Durand G et al. Colonoscopy results of a French regional FOBT-based colorectal cancer screening program with high compliance. Endoscopy 2008; 40: 422-427
64 Denis B, Ruetsch M, Strentz P et al. Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Gut 2007; 56: 1579-1584
65 Tazi MA, Faivre J, Dassonville F et al. Participation in faecal occult blood screening for colorectal cancer in a well defined French population: results of five screening rounds from 1988 to 1996. J Med Screen 1997; 4: 147-151
66 Herbert C, Launoy G, Thezee Y et al. Participants' characteristics in a French colorectal cancer mass screening campaign. Prev Med 1995; 24: 498-502
67 Tifratene K, Eisinger F, Rinaldi Y et al. Colorectal cancer screening program: cost effectiveness of systematic recall letters. Gastroenterol Clin Biol 2007; 31: 929-933
68 Federici A, Giorgi Rossi P, Borgia P et al. The immunochemical faecal occult blood test leads to higher compliance than the guaiac for colorectal cancer screening programmes: a cluster randomized controlled trial. J Med Screen 2005; 12: 83-88
69 Federici A, Marinacci C, Mangia M et al. Is the type of test used for mass colorectal cancer screening a determinant of compliance? A cluster-randomized controlled trial comparing fecal occult blood testing with flexible sigmoidoscopy. . Cancer Detect Prev 2006; 30: 347-353
70 Fric P, Zavoral M, Dvorakova H et al. An adapted program of colorectal cancer screening-7 years experience and cost-benefit analysis. Hepatogastroenterology 1994; 41: 413-416
71 Preisich P, Siba S, Szakatsy E. Mass screening for colorectal cancer in Hungary. J R Soc Med 1987; 80: 352-353
72 Lee FI. Screening for colorectal cancer in a factory-based population with Fecatest. Br J Cancer 1983; 48: 843-847
73 Hart AR, Glover N, Howick-Baker J et al. An industry based approach to colorectal cancer screening in an asymptomatic population. Postgrad Med J 2003; 79: 646-649
74 Hart AR, Eaden J, Barnett S et al. Colorectal cancer prevention. An approach to increasing compliance in a faecal occult blood test screening programme. J Epidemiol Community Health 1998; 52: 818-820
75 Parente F, Marino B, DeVecchi N et al. Faecal occult blood test-based screening programme with high compliance for colonoscopy has a strong clinical impact on colorectal cancer. Br J Surg 2009; 96: 533-540
76 Grazzini G, Ciatto S, Cislaghi C et al. Cost evaluation in a colorectal cancer screening programme by faecal occult blood test in the District of Florence. J Med Screen 2008; 15: 175-181
77 Federici A, Barca A, Baiocchi D et al. Can colorectal cancer mass-screening organization be evidence-based? Lessons from failures: the experimental and pilot phases of the Lazio program. . BMC Public Health 2008; 8: 318
78 Courtier R, Casamitjana M, Macia F et al. Participation in a colorectal cancer screening programme: influence of the method of contacting the target population. Eur J Cancer Prev 2002; 11: 209-213
79 Grazzini G, Castiglione G, Isu A et al. Colorectal cancer screening by fecal occult blood testing: results of a population-based experience. Tumori 2000; 86: 384-388
80 Segnan N, Senore C, Andreoni B et al. Randomized trial of different screening strategies for colorectal cancer: patient response and detection rates. J Natl Cancer Inst 2005; 97: 347-357
81 Segnan N, Senore C, Andreoni B et al. Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening. Gastroenterology 2007; 132: 2304-2312
82 Castiglione G, Zappa M, Grazzini G et al. Screening for colorectal cancer by faecal occult blood test: comparison of immunochemical tests. J Med Screen 2000; 7: 35-37
83 Castiglione G, Zappa M, Grazzini G et al. Immunochemical vs guaiac faecal occult blood tests in a population-based screening programme for colorectal cancer. Br J Cancer 1996; 74: 141-144
84 Armitage N, Hardcastle JD, Amar SS et al. A comparison of an immunological faecal occult blood test Fecatwin sensitive/FECA EIA with Haemoccult in population screening for colorectal cancer. Br J Cancer 1985; 51: 799-804
85 Hoff G, Bretthauer M. Appointments timed in proximity to annual milestones and compliance with screening: randomised controlled trial. BMJ 2008; 337: 2794
86 Hoff G, Vatn M, Gjone E et al. Epidemiology of polyps in the rectum and sigmoid colon. Design of a population screening study. Scand J Gastroenterol 1985; 20: 351-355
87 Blom J, Liden A, Jeppsson B et al. Compliance and findings in a Swedish population screened for colorectal cancer with sigmoidoscopy. Eur J Surg Oncol 2002; 28: 827-831
88 Santavirta J. Screening, sigmoidoscopy in persons aged 60 years. Colorectal Dis 2002; 4: 184-188
89 Bleiberg H, Autier P, Huet F et al. Colorectal cancer (CRC) screening using sigmoidoscopy followed by colonoscopy: a feasibility and efficacy study on a cancer institute based population. Ann Oncol 2006; 17: 1328-1332
90 Brotherstone H, Vance M, Edwards R et al. Uptake of population-based flexible sigmoidoscopy screening for colorectal cancer: a nurse-led feasibility study. J Med Screen 2007; 14: 76-80
91 Gray M, Pennington CR. Screening sigmoidoscopy: a randomised trial of invitation style. Health Bull 2000; 58: 137-140
92 Senore C, Segnan N, Rossini FP et al. Screening for colorectal cancer by once only sigmoidoscopy: a feasibility study in Turin, Italy. J Med Screen 1996; 3: 72-78
93 Brotherstone H, Miles A, Robb KA et al. The impact of illustrations on public understanding of the aim of cancer screening. Patient Educ Couns 2006; 63: 328-335
94 Pye G, Christie M, Chamberlain JO et al. A comparison of methods for increasing compliance within a general practitioner based screening project for colorectal cancer and the effect on practitioner workload. J Epidemiol Community Health 1988; 42: 66-71
95 Thomas WM, Pye G, Hardcastle JD et al. Faecal occult blood screening for colorectal neoplasia: a randomized trial of three days or six days of tests. Br J Surg 1990; 77: 277-279
96 Robinson MH, Pye G, Thomas WM et al. Haemoccult screening for colorectal cancer: the effect of dietary restriction on compliance. Eur J Surg Oncol 1994; 20: 545-548
97 Robinson MH, Marks CG, Farrands PA et al. Screening for colorectal cancer with an immunological faecal occult blood test: 2-year follow-up. Br J Surg 1996; 83: 500-501
98 Marbet UA, Bauerfeind P, Brunner J et al. Colonoscopy is the preferred colorectal cancer screening method in a population-based program. Endoscopy 2008; 40: 650-655
99 Corbett M, Chambers SL, Shadbolt B et al. Colonoscopy screening for colorectal cancer: the outcomes of two recruitment methods. Med J Aust 2004; 181: 423-427
100 Cole SR, Young GP, Esterman A et al. A randomised trial of the impact of new faecal haemoglobin test technologies on population participation in screening for colorectal cancer. J Med Screen 2003; 10: 117-122
101 Hughes K, Leggett B, Del Mar C et al. Guaiac versus immunochemical tests: faecal occult blood test screening for colorectal cancer in a rural community. Aust N Z J Public Health 2005; 29: 358-364
102 King J, Fairbrother G, Thompson C et al. Colorectal cancer screening: optimal compliance with postal faecal occult blood test. Aust N Z J Surg 1992; 62: 714-719
103 Dent OF, Bartrop R, Goulston KJ et al. Participation in faecal occult blood screening for colorectal cancer. Soc Sci Med 1983; 17: 17-23
104 Multicentre Australian Colorectal-neoplasia Screening (MACS) group. A comparison of colorectal neoplasia screening tests: A multicentre community-based study of the impact of consumer choice. Med J Aust 2006; 184: 546-550
105 Cole SR, Smith A, Wilson C et al. An advance notification letter increases participation in colorectal cancer screening. J Med Screen 2007; 14: 73-75
106 Cole SR, Young GP, Byrne D et al. Participation in screening for colorectal cancer based on a faecal occult blood test is improved by endorsement by the primary care practitioner. J Med Screen 2002; 9: 147-152
107 Scott RG, Edwards JT, Fritschi L et al. Community-based screening by colonoscopy or computed tomographic colonography in asymptomatic average-risk subjects. Am J Gastroenterol 2004; 99: 1145-1151
108 Edwards JT, Mendelson RM, Fritschi L et al. Colorectal neoplasia screening with CT colonography in average-risk asymptomatic subjects: community-based study. Radiology 2004; 230: 459-464
109 Collett JA, Olynyk JK, Platell CF. Flexible sigmoidoscopy screening for colorectal cancer in average-risk people: update of a community-based project. Med J Aust 2000; 173: 463-466
110 Segarajasingam DS, Ang EBH, Fritschi L et al. Seasonal variation of participation in colorectal neoplasia screening by colonoscopy or CT colonography. Aust N Z J Public Health 2006; 30: 287-288
111 Krevsky B, Niewiarowski T, League R et al. Flexible sigmoidoscopy screening in an industrial setting. Am J Gastroenterol 1992; 87: 1759-1762
112 Elwood TW, Erickson A, Lieberman S. Comparative educational approaches to screening for colorectal cancer. Am J Public Health 1978; 68: 135-138
113 Myers R, Trock B, Lerman C et al. Adherence to colorectal cancer screening in an HMO population. Prev Med 1990; 19: 502-514
114 Myers RE, Ross EA, Wolf TA et al. Behavioral interventions to increase adherence in colorectal cancer screening. Medical Care 1991; 29: 1039-1050
115 Nichols S, Koch E, Lallemand RC et al. Randomised trial of compliance with screening for colorectal cancer. Br Med J (Clin Res Ed) 1986; 293: 107-110
116 Schroy PC, Wilson S, Afdhal N. Feasibility of high-volume screening sigmoidoscopy using a flexible fiberoptic endoscope and a disposable sheath system. Am J Gastroenterol 1996; 91: 1331-1337
117 Neale AV, Demers RY, Herman S. Compliance with colorectal cancer screening in a high-risk occupational group. J Occup Med 1989; 31: 1007-1012
118 Vernon SW, Acquavella JF, Douglass TS et al. Factors associated with participation in an occupational program for colorectal cancer screening. J Occup Med 1989; 31: 458-463
119 Walsh JM, Salazar R, Terdiman JP et al. Promoting use of colorectal cancer screening tests. Can we change physician behavior? . J Gen Intern Med 2005; 20: 1097-1101
120 Percac-Lima S, Grant RW, Green AR et al. A culturally tailored navigator program for colorectal cancer screening in a community health center: A randomized, controlled trial. J Gen Intern Med 2009; 24: 211-217
121 Vinker S, Nakar S, Rosenberg E et al. The role of family physicians in increasing annual fecal occult blood test screening coverage: a prospective intervention study. Isr Med Assoc J 2002; 4: 424-425
122 Wei N, Nakama H, Li T. Screen compliance rates in 14-years annual screening program for colorectal cancer with immunochemical fecal occult blood test -- identification of higher priority subjects in health education. Eur J Med Res 1998; 3: 341-344
123 Slater PE, Fich A, Zimmerman J et al. Recruitment of subjects for fecal occult blood screening: a comparison of two methods in Jerusalem. J Clin Gastroenterol 1985; 7: 51-54
124 Ore L, Hagoel L, Lavi I et al. Screening with faecal occult blood test (FOBT) for colorectal cancer: assessment of two methods that attempt to improve compliance. Eur J Cancer Prev 2001; 10: 251-256
125 Elliot MS, Levenstein JH, Wright JP. Faecal occult blood testing in the detection of colorectal cancer. Br J Surg 1984; 71: 785-786
126 Bat L, Pines A, Ron E et al. A community-based program of colorectal screening in an asymptomatic population: evaluation of screening tests and compliance. Am J Gastroenterol 1986; 81: 647-651
127 Niv Y, Lev-El M, Fraser G et al. Protective effect of faecal occult blood test screening for colorectal cancer: worse prognosis for screening refusers. Gut 2002; 50: 33-37
128 Hou SI, Chen PH. Home-administered fecal occult blood test for colorectal cancer screening among worksites in Taiwan. Prev Med 2004; 38: 78-84
129 Niv Y, Gold B, Fraser GM. Screening for colonic neoplastic lesions using flexible sigmoidoscopy in employees of a nuclear research center and members of collective settlements. Isr J Med Sci 1996; 32: 1167-1172
130 Levi Z, Chorev N, Segal N et al. Screening for colorectal cancer in personnel of an academic medical center. Dig Dis Sci 2007; 52: 2301-2304
131 Power E, Miles A, von Wagner C et al. Uptake of colorectal cancer screening: system, provider and individual factors and strategies to improve participation. Future Oncol 2009; 5: 1371-1388
132 Centers for Disease Control and Prevention (CDC). Use of colorectal cancer tests-United States, 2002, 2004, and 2006. MMWR Morb Mortal Wkly Rep 2008; 57: 253-258
133 Sonnenberg A, Delco F, Inadomi JM. Cost-effectiveness of colonoscopy in screening for colorectal cancer. Ann Intern Med 2000; 133: 573-584
134 Bastos J, Peleteiro B, Gouveia J et al. The state of the art of cancer control in 30 European countries in 2008. Int J Cancer 2010; 126: 2700-2715
135 Saito H. Colorectal cancer screening using immunochemical faecal occult blood testing in Japan. J Med Screen 2006; 13: 6-7
136 Brenner H, Hoffmeister M, Brenner G et al. Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies. Eur J Cancer 2009; 45: 2027-2033
137 Haidinger G, Waldhoer T, Vutuc C. Self-reported colonoscopy screening in Austria. Eur J Cancer Prev 2008; 17: 354-357
138 Keighley MR, O’Morain C, Giacosa A et al. Public awareness of risk factors and screening for colorectal cancer in Europe. Eur J Cancer Prev 2004; 13: 257-262
138 Robinson MH, Marks CG, Farrands PA et al. Population screening for colorectal cancer: comparison between guaiac and immunological faecal occult blood tests. Br J Surg 1994; 3: 448-451
138 Bleiberg H, Autier P, Huet F et al. Colorectal cancer (CRC) screening using sigmoidoscopy followed by colonoscopy: a feasibility and efficacy study on a cancer institute based population. Annals of Oncology. 2006; 1328-1332

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Supplementary material